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The 4D Nucleome (4DN) Data Coordination and Integration Center (DCIC) aims to collect, store, curate, display, and analyze data generated in the 4DN Network. The DCIC is a collaboration of two centers from three institutions: Harvard University, Massachusetts Institute of Technology (MIT), and The Washington University in St. Louis (WashU). The Harvard/MIT DCIC is tasked with building the infrastructure for data collection and integration. The Harvard/MIT and WashU centers will collaborate on the development and incorporation of novel data visualization tools.

Our team of investigators and staff has a track record in analysis of chromatin interaction data, image processing, data visualization, integrative analysis of genomic and epigenomic data, data portal development, large-scale computing, and development of secure and flexible Cloud technologies. We will develop efficient submission pipelines for data and metadata from 4DN data production groups and we will define data/metadata requirements and quality metrics in conjunction with the production groups and ensure that high-quality, well-annotated data become available to the wider scientific community in a timely manner.

Furthermore, we will develop a user-friendly data portal for the broad scientific community. This portal will provide an easy-to-navigate interface for accessing raw and intermediate data files, allow for programmatic access via APIs, and will incorporate the analysis and visualization tools developed by DCIC as well as other Network members. For computing and storage scalability and cost-effectiveness, significant efforts will be devoted to development and deployment of cloud-based technology. We will conduct tutorials and workshops to facilitate the use of 4DN data and tools by external investigators.

Ultimately, we will coordinate and assist in conducting integrative analysis of the multiple data types. These efforts will examine key questions in higher-order chromatin organization using both sequence and image data, and the tools and algorithms developed here will be incorporated into the data portal for use by other investigators. By completing these tasks, we will ensure that the data generated in 4DN will have maximal impact for the scientific community.

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